![]() ![]() Despite nearly a century of research, the exact mechanism yielding improved lifespan under CR is unclear. ![]() Calorie restrictionĬR has been demonstrated to delay the impacts of aging and extend lifespan across a variety of species, from simple yeast to complex multicellular organisms such as mice and non-human primates (NHP). It is hypothesized that these variations of dietary restriction (DR) enhance longevity and metabolic health through molecular adaptations of nutrient-sensing pathways including, but not limited to, the mechanistic target of rapamycin complex 1 (mTORC1), AKT, FOXO, nicotinamide adenine dinucleotide (NAD +), and AMP-activated protein kinase (reviewed in ). The research presented can be broadly separated into a few main categories, including nutritional interventions, senescence and stem cells, metabolic homeostasis, and immunity.Ī wide variety of dietary regimens, such as dietary protein restriction (PR), calorie restriction (CR), fasting, time-restricted feeding, and more, are under investigation for their roles in health span and lifespan extension. Rozalyn Anderson, a MAC founder and the 2019–2021 AGE President, organized a spectacular event, with over 380 in person and virtual attendees this article will summarize the science that members of MAC institutions presented at this meeting. Many members of the MAC as well as other aging experts convened at the 2021 Annual Meeting of the American Aging Association in Madison, WI, home to the University of Wisconsin-Madison. The MAC now spans 7 states in the Midwestern United States, and includes the Mayo Clinic the Universities of Wisconsin–Madison, Minnesota, Iowa, Northwestern, and North Dakota Iowa State University Southern Illinois University Indiana University-Bloomington and The Ohio State University. In order to leverage the respective strengths of different programs, centers, and institutes of aging across the Midwestern region to accelerate basic and translational geroscience, and to provide a strong training environment for postdoctoral fellows and graduate students, the Midwest Aging Consortium (MAC ) was organized in 2019, with an in-person symposium in 2019 and a virtual symposium in 2021. Due to the complexity of aging, geroscience research necessarily spans a variety of disciplines and requires a collaborative and interdisciplinary approach. GeroScience volume 44, pages 39–52 ( 2022) Cite this articleĪs the aging population on a global and national scale reaches ever increasing highs, research is essential to reduce the burden of aging and age-related diseases. Metabolism in the Midwest: research from the Midwest Aging Consortium at the 49 th Annual Meeting of the American Aging Association ![]()
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